InnoSeal is a biodegradable stretchy polysaccharide-based material that has been successfully tested as a sealant for large caliber vascular grafts (100% patency).  It is designed to be sufficiently tough and is sterilizable with a shelf life measured in years; however, when implanted in the body it degrades over a period of months and is replaced by living tissue. InnoSeal can be used with small caliber vascular grafts as well as be injected directly in the body as a bulking agent. 

This sealant was developed as a synthetic-replacement to animal-based sealants on the market, including collagen, albumen, and gelatin. The synthetic equivalent of these sealants will be valuable should countries begin to outlaw animal-based sealants that have the potential to carry prions for mad cow disease or which may cause allergic reactions in some people.

Quatromer is a thermoset material and is designed to be injected into various cavities in the body. The viscous material is comprised of mainly PIB with active cyanoacrylate end-groups that, when mixed together with an activator, crosslink to form a solid, rubbery material. This material is similar to that used for racing car tires; however, it does not contain the vulcanizing agents used in rubber chemistry which are toxic in the body. 

This PIB-based thermoset material is injection-molded and then heat-cured to arrive at the final crosslinked product. The heat curing of Quatroset causes it to crosslink in three dimensions, which enhances its physical properties. Crosslinked PIB-based polymers will demonstrate minimal creep with time, thereby rendering them more desirable for load-bearing applications requiring memory, such as heart valves, vertebral disks, acetabular joints and menisci.